Regulatory T cells suppress CD 4 + T cells through NFAT ‐dependent transcriptional mechanisms

Regulatory T cells suppress CD4+ T cells through NFAT-dependent transcriptional mechanisms.

Regulatory T cells (Tregs) control autoreactive T cells by inhibiting activation-induced proliferation and cytokine expression. The molecular mechanisms responsible for the inactivation of effector T cells by Tregs remain yet to be fully characterized. We report that T-helper cells stimulated in the presence of Tregs quickly activate NFAT1 and have increased NFAT1-dependent expression of the tr...

suppress murine GVHD in a mechanism independent of CD 4 + CD 25 + regulatory T cells

To investigate the role of mast cells in hematopoietic cell transplantation, we assessed graft vs. host disease (GVHD) in C57BL/6-Kit recipients, which virtually lack mast cells, as compared to C57BL/6 WT recipients. GVHD was severely exacerbated in C57BL/6-Kit mice (median survival time, MST = 13 days vs. 60 days in WT mice; p<0.0001). The increased mortality risk in C57BL/6-Kit hosts correlat...

T Cells from Naive CD 4 T Cells CD 28 Controls Differentiation of Regulatory

Regulatory T Cells in Colorectal Cancer

One of the essential protection mechanisms of immune system is Treg cells which play an important role in maintenance ofimmune homeostasis. However, they may also inhibit immune functions against tumor cells. It has been reported that Treg cellsare increased in patients suffering from different types of cancer. Increased number of Treg cells has been shown in tumor lymphnodes, peripheral blood,...

Cellthe Peripheral Activated / Memory CD 4 T Regulatory CD 4 T Cells Control